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VASCULAR BIOLOGY

Endothelial metabolism—more complex (III) than previously thought

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The growth of new blood vessels (angiogenesis) is a bio-energetically demanding process. Surprisingly, the specific role of mitochondria in angiogenesis remains unclear. A study in this issue of Nature Metabolism now demonstrates that mitochondrial respiration is essential for angiogenic growth by controlling endothelial proliferation.

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Fig. 1: Mitochondrial respiration supports endothelial proliferation.

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Authors and Affiliations

  1. Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

    Jorge Andrade & Michael Potente

  2. International Institute of Molecular and Cell Biology, Warsaw, Poland

    Michael Potente

  3. DZHK (German Center for Cardiovascular Research), Frankfurt Rhine-Main, Berlin, Germany

    Michael Potente

Authors
  1. Jorge Andrade
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  2. Michael Potente
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Correspondence to Michael Potente.

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The authors declare no competing interests.

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Andrade, J., Potente, M. Endothelial metabolism—more complex (III) than previously thought. Nat Metab 1, 14–15 (2019). https://doi.org/10.1038/s42255-018-0019-2

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