Skip to main content
Log in

Enzymes

Taking a walk to find new mucinases

  • News & Views
  • Published:

From Nature Catalysis

View current issue Submit your manuscript

Gut microbes have enzymes that break down the heavily glycosylated mucin protein of host animals, but known enzymes recognize only one glycan chain. Now, bioinformatic exploration has uncovered a family of mucinases that targets dense sugar residues.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: A mucinase specific for dense glycans.

References

  1. Hansson, G. C. Annu. Rev. Biochem. 89, 769–793 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Shon, D. J., Kuo, A., Ferracane, M. J. & Malaker, S. A. Biochem. J. 478, 1585–1603 (2021).

    Article  CAS  PubMed  Google Scholar 

  3. Narimatsu, Y. et al. Nat. Catal. https://doi.org/10.1038/s41929-024-01116-5 (2024).

  4. Luis, A. S. & Hansson, G. C. Cell Host Microbe 31, 1087–1100 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Perdam, K. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01840-6 (2023).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shinya Fushinobu.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fushinobu, S. Taking a walk to find new mucinases. Nat Catal 7, 345–346 (2024). https://doi.org/10.1038/s41929-024-01145-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41929-024-01145-0

  • Springer Nature Limited

Navigation