Enantioselective synthesis of chiral cyclobutanes via direct cycloaddition of C–C single bonds with C=C double bonds has remained an unmet challenge. Now, a photoelectrocatalytic system enabling asymmetric dehydrogenative [2+2] cycloaddition of alkyl ketones and alkenes has been developed.
This is a preview of subscription content, log in via an institution to check access.
References
Poplata, S., Tröster, A., Zou, Y.-Q. & Bach, T. Chem. Rev. 116, 9748–9815 (2016).
Wu, S., Kaur, J., Karl, T. A., Tian, X. & Barham, J. P. Angew. Chem. Int. Ed. 61, e202107811 (2022).
Huang, H., Steiniger, K. A. & Lambert, T. H. J. Am. Chem. Soc. 144, 12567–12583 (2022).
Xiong, P., Ivlev, S. I. & Meggers, E. Nat. Catal. https://doi.org/10.1038/s41929-023-01050-y (2023).
Huang, X. & Meggers, E. Acc. Chem. Res. 52, 833–847 (2019).
Huang, X. et al. J. Am. Chem. Soc. 139, 9120–9123 (2017).
Huang, X., Zhang, Q., Lin, J., Harms, K. & Meggers, E. Nat. Catal. 2, 34–40 (2019).
Xiong, P., Hemming, M., Ivlev, S. I. & Meggers, E. J. Am. Chem. Soc. 144, 6964–6971 (2022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Tao, Y., Huang, C. & Lu, Q. Cycloaddition with asymmetric photoelectrocatalysis. Nat Catal 6, 1107–1108 (2023). https://doi.org/10.1038/s41929-023-01071-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41929-023-01071-7
- Springer Nature Limited