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Biocatalysis

CYP screening for a better terpenoid world

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Diverse cytochrome P450s (CYPs) in nature can modify terpenoid scaffolds toward products with higher structural complexity and chemical diversity, but their discovery remains challenging. Now, an Escherichia coli -based gene screening platform enables high-throughput bacterial CYP screening, leading to efficient and diverse terpenoid biosynthesis.

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Fig. 1: An engineered E. coli platform enables bacterial CYP screening and diverse terpenoid biosynthesis.

References

  1. Christianson, D. W. Chem. Rev. 117, 11570–11648 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Zeng, T. et al. J. Chem. Inf. Model. 60, 2082–2090 (2020).

    Article  CAS  PubMed  Google Scholar 

  3. White, N. J. Science 320, 330–334 (2008).

    Article  CAS  PubMed  Google Scholar 

  4. Guo, J. et al. New Phytol. 210, 525–534 (2016).

    Article  CAS  PubMed  Google Scholar 

  5. Bernhardt, R. & Urlacher, V. B. Appl. Microbiol. Biotechnol. 98, 6185–6203 (2014).

    Article  CAS  PubMed  Google Scholar 

  6. Xiao, H., Zhang, Y. & Wang, M. Trends Biotechnol. 37, 618–631 (2019).

    Article  CAS  PubMed  Google Scholar 

  7. Lin, G.-M. & Voigt, C. A. Nat. Catal. https://doi.org/10.1038/s41929-023-01049-5 (2023).

    Article  Google Scholar 

  8. Meyer, A. J. et al. Nat. Chem. Biol. 15, 196–204 (2019).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA

    Jianing Han & Sijin Li

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  1. Jianing Han
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  2. Sijin Li
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Correspondence to Sijin Li.

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The authors declare no competing interests.

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Han, J., Li, S. CYP screening for a better terpenoid world. Nat Catal 6, 983–984 (2023). https://doi.org/10.1038/s41929-023-01064-6

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