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Catalytic RNA

Choreography of a self-splicing ribozyme

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The discovery of the Tetrahymena group I intron’s self-splicing defined RNAs as capable catalysts. Now, cryogenic electron microscopy structures of this ribozyme have revealed large conformational changes and mechanistic details of its two-step mode of action.

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Fig. 1: Proposed states of Tetrahymena group I intron (Tet) during self-splicing.

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Authors and Affiliations

  1. Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA

    Kyle H. Cole & Andrej Lupták

  2. Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA

    Katrina Mogannam & Andrej Lupták

  3. Department of Chemistry, University of California, Irvine, CA, USA

    Andrej Lupták

Authors
  1. Kyle H. Cole
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  2. Katrina Mogannam
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  3. Andrej Lupták
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Correspondence to Andrej Lupták.

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Cole, K.H., Mogannam, K. & Lupták, A. Choreography of a self-splicing ribozyme. Nat Catal 6, 291–293 (2023). https://doi.org/10.1038/s41929-023-00948-x

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