The introduction of single abiological catalytic groups enables enzymes to catalyse new-to-nature chemical transformations. Now, this concept is extended to two abiological groups in a single protein scaffold to allow synergistic catalysis in a stereoselective Michael addition reaction.
This is a preview of subscription content, log in via an institution to check access.
References
Bornscheuer, U. T. et al. Nature 485, 185–194 (2012).
Honig, M., Sondermann, P., Turner, N. J. & Carreira, E. M. Angew. Chem. Int. Ed. 56, 8942–8973 (2017).
Schwizer, F. et al. Chem. Rev. 118, 142–231 (2018).
Brandenberg, O. F., Fasan, R. & Arnold, F. H. Curr. Opin Biotechnol. 47, 102–111 (2017).
Zhou, Z. & Roelfes, G. Nat. Catal. https://doi.org/10.1038/s41929-019-0420-6 (2020).
Jeschek, M. et al. Nature 537, 661–665 (2016).
Sreenilayam, G., Moore, E. J., Steck, V. & Fasan, R. ACS Catal. 7, 7629–7633 (2017).
Mirts, E. N., Bhagi-Damodaran, A. & Lu, Y. Acc. Chem. Res. 52, 935–944 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Ren, X., Fasan, R. Synergistic catalysis in an artificial enzyme. Nat Catal 3, 184–185 (2020). https://doi.org/10.1038/s41929-020-0435-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41929-020-0435-z
- Springer Nature Limited