Simple methods to incorporate deuterium into organic compounds are highly sought after as deuteration can enable mechanistic studies or improve the metabolic stability of pharmaceuticals. Now, a catalytic hydrogen–deuterium exchange reaction using deuterated water allows convenient access to deuterated aldehyde building blocks.
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Anthony, S.M., Kelleghan, A.V., Mehta, M.M. et al. From heavy water to heavy aldehydes. Nat Catal 2, 1058–1059 (2019). https://doi.org/10.1038/s41929-019-0393-5
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DOI: https://doi.org/10.1038/s41929-019-0393-5
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