Given the importance of enantioenriched β2- and β3-amino acids as building blocks, direct and versatile methods for their synthesis are highly coveted by organic chemists. Now, using easily accessible 1,3-oxazinane motifs, a regiodivergent and enantioselective C–H functionalization method permits their synthesis in a straightforward and practical fashion.
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Planas, O., Cornella, J. Facile access to chiral non-natural amino acids. Nat Catal 2, 839–840 (2019). https://doi.org/10.1038/s41929-019-0367-7
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DOI: https://doi.org/10.1038/s41929-019-0367-7
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