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BIOORTHOGONAL CATALYSIS

Exosomes for cell-targeted bioorthogonal catalysis

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Transition metal-catalysed bioorthogonal reactions are severely hindered in biomedical applications, mainly due to a lack of target specificity. Now, research shows that a trojan exosome vesicle can deliver a palladium catalyst specifically to progenitor cells for bioorthogonal catalysis, allowing localized prodrug activation.

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Fig. 1: Scheme of preparation and intracellular catalysis of Pd-loaded exosomes.

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Authors and Affiliations

  1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China

    Zhi Du & Xiaogang Qu

  2. University of Chinese Academy of Sciences, Beijing, China

    Zhi Du

Authors
  1. Zhi Du
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  2. Xiaogang Qu
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Correspondence to Xiaogang Qu.

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Du, Z., Qu, X. Exosomes for cell-targeted bioorthogonal catalysis. Nat Catal 2, 837–838 (2019). https://doi.org/10.1038/s41929-019-0350-3

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  • DOI: https://doi.org/10.1038/s41929-019-0350-3

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