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CATALYTIC DNA

How DNA catalyses RNA ligation

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A synthetic DNA enzyme catalyses the formation of a native phosphodiester bond between two RNA fragments, but the molecular details of the mechanism remained elusive. Research using computational and biochemical approaches now suggests that the DNA enzyme recruits two magnesium ions to assist in the catalysis of RNA ligation.

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Fig. 1: DNA-catalysed RNA ligation.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Julius-Maximilians-University Würzburg, Würzburg, Germany

    Claudia Höbartner

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  1. Claudia Höbartner
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Correspondence to Claudia Höbartner.

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Höbartner, C. How DNA catalyses RNA ligation. Nat Catal 2, 483–484 (2019). https://doi.org/10.1038/s41929-019-0295-6

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