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BIOCATALYSIS

Amine dehydrogenases occur in nature

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The diversity of engineered amine dehydrogenases for reductive amination remains limited. Now, native amino dehydrogenases offering a different sequence space and catalytic features are discovered — enhancing and broadening the biocatalysis toolbox.

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Fig. 1: Asymmetric reductive amination of ketones catalysed by amine dehydrogenases.

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Correspondence to Andreas S. Bommarius.

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Bommarius, A.S. Amine dehydrogenases occur in nature. Nat Catal 2, 288–289 (2019). https://doi.org/10.1038/s41929-019-0270-2

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