Skip to main content
SpringerLink
Log in

NATURAL PRODUCT BIOSYNTHESIS

Pathway to malonic acid-containing metabolites

  • News & Views
  • Published:

From Nature Catalysis

View current issue Submit your manuscript

A crucial malonic acid moiety in the antibiotic malonomycin has been shown to be installed by a bacterial vitamin K-dependent (VKD) carboxylase orthologue.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Fig. 1: Overview of malonomycin biosynthesis.

References

  1. Newman, D. J. & Cragg, G. M. J. Nat. Prod. 79, 629–661 (2016).

    Article  CAS  PubMed  Google Scholar 

  2. Dodge, G. J., Maloney, F. P. & Smith, J. L. Nat. Prod. Rep. 35, 1082–1096 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Izoré, T. & Cryle, M. J. Nat. Prod. Rep. https://doi.org/10.1039/C8NP00038G (2018).

    Article  PubMed  Google Scholar 

  4. Law, B. J. C. et al. Nat. Catal. https://doi.org/10.1038/s41929-018-0178-2 (2018).

    Article  Google Scholar 

  5. Stenflo, J., Fernlund, P., Egan, W. & Roepstorff, P. Proc. Natl Acad. Sci. USA 71, 2730–2733 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Patteson, J. B., Dunn, Z. D. & Li, B. Angew. Chem. Int. Ed. Engl. 57, 6780–6785 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gaudelli, N. M., Long, D. H. & Townsend, C. A. Nature 520, 383–387 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Haslinger, K., Peschke, M., Brieke, C., Maximowitsch, E. & Cryle, M. J. Nature 521, 105–109 (2015).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

    Max J. Cryle

  2. ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia

    Max J. Cryle

  3. EMBL Australia, Monash University, Clayton, Victoria, Australia

    Max J. Cryle

  4. Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Heidelberg, Germany

    Max J. Cryle

Authors
  1. Max J. Cryle
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Max J. Cryle.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cryle, M.J. Pathway to malonic acid-containing metabolites. Nat Catal 1, 907–908 (2018). https://doi.org/10.1038/s41929-018-0191-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41929-018-0191-5

  • Springer Nature Limited

Search

Navigation