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Aging

Investigating trajectories of aging using high-dimensional phenotyping in mice

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Despite centuries of effort from philosophers, physicians and biologists, the answer to the seemingly simple question “what is aging?” remains elusive. Some even posit that aging represents a phenomenon too expansive to ever be succinctly defined. A new study tackles this question by profiling hundreds of phenotypes across age in mice and examining how the trajectories of these phenotypes are altered by geroprotective genetic and dietary interventions.

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Fig. 1: Models of age-sensitive phenotype (ASP) responses to geroprotective interventions.

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Authors and Affiliations

  1. Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA

    Michael R. MacArthur & Sarah J. Mitchell

  2. Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton, NJ, USA

    Sarah J. Mitchell

Authors
  1. Michael R. MacArthur
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  2. Sarah J. Mitchell
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Correspondence to Sarah J. Mitchell.

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The authors declare no competing interests.

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MacArthur, M.R., Mitchell, S.J. Investigating trajectories of aging using high-dimensional phenotyping in mice. Lab Anim 52, 61–62 (2023). https://doi.org/10.1038/s41684-023-01122-3

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