Strain contributions arising from the strain of origin and backcrosses can modify phenotypic severity and/or penetrance of mutant alleles in mouse models.
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Acknowledgements
MGD is supported by program project grant HG000330 from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).
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Perry, M.N., Bello, S.M. & Smith, C.L. Know Your Model: Why mouse inbred strain contribution matters. Lab Anim 49, 133–134 (2020). https://doi.org/10.1038/s41684-020-0525-1
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DOI: https://doi.org/10.1038/s41684-020-0525-1
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