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Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains

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Microglia play important but incompletely understood roles in the pathogenesis of neurological disease. New chimeric models using transplanted human stem cell-derived microglia-like cells hold great promise to better model the unique function of human microglia in brain disease.

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Fig. 1: Human microglia/mouse brain chimeras for the study of AD-related transcriptional changes unique to human microglia in vivo.

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Author information

Authors and Affiliations

  1. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Fadi Jacob

  2. Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Fadi Jacob

  3. Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Fadi Jacob

  4. Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    Mariko L. Bennett

Authors
  1. Fadi Jacob
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  2. Mariko L. Bennett
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Correspondence to Fadi Jacob.

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Jacob, F., Bennett, M.L. Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains. Lab Anim 49, 49–51 (2020). https://doi.org/10.1038/s41684-019-0465-9

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  • DOI: https://doi.org/10.1038/s41684-019-0465-9

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