A pilot study investigating anterior segment optical coherence tomography angiography as a non-invasive tool in evaluating corneal vascularisation

Table 1 Linear mixed-effects model analyses comparing serial anterior segment optical coherence tomography angiography (AS-OCTA) determined parameters (vessel density, vessel branch area, vessel width) to indocyanine green angiography (ICGA) determined corneal vascularisation staging.

ICGA corneal vascularisation staging
Total (n = 15)^a	Stage 1 and 2 (n = 7)^a	Stage 3 (n = 3)^a			Stage 4 and 5 (n = 5)^a
AS-OCTA vascular parameters	Mean ± SD	Mean ± SD	Mean difference	P-value	Mean ± SD	Mean difference	P-value
Vessel density	40.46 ± 2.12	13.14 ± 3.26	27.32 ± 4.78	0.005	27.29 ± 1.80	13.17 ± 3.13	0.006
Vessel branching	30.23 ± 2.54	8.73 ± 3.74	21.50 ± 5.32	0.007	20.76 ± 2.08	9.47 ± 3.26	0.05
Vessel width	1.26 ± 0.13	1.44 ± 0.20	− 0.19 ± 0.30	0.99	1.47 ± 0.14	− 0.20 ± 0.24	0.99

^aObserved number of images at various stages of corneal vascularisation through serial AS-OCTA and ICGA imagings.