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Cytoskeleton

Unveiling the secrets of vimentin filament architecture relevant to human disease

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The human cytoskeleton consists of three major classes of filaments: microfilaments, microtubules and intermediate filaments. Here, we summarize recent progress in deciphering the structure and function of intermediate filaments and their implications for human disease.

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Fig. 1: Schematic of vimentin IF structure and assembly based on cryo-ET and cryo-EM data.

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Acknowledgements

This work was supported by the United States National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases under award number R01 AR079428 (to C.G.B.).

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Authors and Affiliations

  1. Department of Dermatology, Yale School of Medicine, New Haven, CT, USA

    Ivan B. Lomakin, Minh Ho & Christopher G. Bunick

  2. Program in Translational Biomedicine, Yale University, New Haven, CT, USA

    Christopher G. Bunick

Authors
  1. Ivan B. Lomakin
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  2. Minh Ho
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  3. Christopher G. Bunick
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Corresponding author

Correspondence to Christopher G. Bunick.

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Competing interests

C.G.B. and M.H. declare patents filed for therapeutic targeting of IFs.

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Lomakin, I.B., Ho, M. & Bunick, C.G. Unveiling the secrets of vimentin filament architecture relevant to human disease. Nat Struct Mol Biol (2024). https://doi.org/10.1038/s41594-024-01301-x

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