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Meiotic recombination

A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss

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Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-analysis of genome-wide association studies, researchers identified a genetic variant that seems to increase risk of pregnancy loss by dysregulating meiotic recombination between homologous chromosomes during egg formation.

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Fig. 1: Protein components of the central element of the synaptonemal complex.

References

  1. Steinthorsdottir, V. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01209-y (2024).

    Article  PubMed  Google Scholar 

  2. Quenby, S. et al. Lancet 397, 1658–1667 (2021).

    Article  CAS  PubMed  Google Scholar 

  3. Macklon, N. S., Geraedts, J. P. M. & Fauser, B. C. J. M. Hum. Reprod. Update 8, 333–343 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. McCoy, R. C. et al. Genome Med. 15, 77 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Boyle, E. A., Li, Y. I. & Pritchard, J. K. Cell 169, 1177–1186 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Nguyen Ba, A. N. et al. Elife 11, e73983 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Bolcun-Filas, E. et al. J. Cell Biol. 176, 741–747 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Dunce, J. M., Salmon, L. J. & Davies, O. R. Nat. Struct. Mol. Biol. 28, 681–693 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Halldorsson, B. V. et al. Science 363, eaau1043 (2019).

    Article  CAS  PubMed  Google Scholar 

  10. Hassold, T. J. & Hunt, P. A. Prenat. Diagn. 41, 584–590 (2021).

    Article  PubMed  Google Scholar 

  11. Gudbjartsson, D. F. et al. Nat. Genet. 47, 435–444 (2015).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

S.A.C. is supported by a US National Science Foundation Graduate Research Fellowship (1746891). R.C.M. is supported by US National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) Award R35GM133747. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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  1. Department of Biology, Johns Hopkins University, Baltimore, MD, USA

    Sara A. Carioscia & Rajiv C. McCoy

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  1. Sara A. Carioscia
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  2. Rajiv C. McCoy
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Correspondence to Rajiv C. McCoy.

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The authors declare no competing interests.

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Carioscia, S.A., McCoy, R.C. A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss. Nat Struct Mol Biol 31, 584–585 (2024). https://doi.org/10.1038/s41594-024-01269-8

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