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Protein biogenesis

Protein import into mitochondria — a new path through the membranes

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The mitochondrial translocase complex TIM23 targets several hundreds of proteins to their location in the mitochondrial matrix or inner membrane. Recent studies provide important structural and mechanistic insights into the actions of the protein-import machinery in mitochondria.

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Fig. 1: Mitochondrial protein-import machineries, with a focus on the TOM and TIM23 complexes.
Fig. 2: Mechanisms of presequence-driven protein import into mitochondria.

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Acknowledgements

This work was funded by the National Science Centre, Poland (grants 2019/35/B/NZ3/04066 and 2019/35/B/NZ3/04095).

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Correspondence to Agnieszka Chacinska.

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Wasilewski, M., Draczkowski, P. & Chacinska, A. Protein import into mitochondria — a new path through the membranes. Nat Struct Mol Biol 30, 1831–1833 (2023). https://doi.org/10.1038/s41594-023-01170-w

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