The mitochondrial translocase complex TIM23 targets several hundreds of proteins to their location in the mitochondrial matrix or inner membrane. Recent studies provide important structural and mechanistic insights into the actions of the protein-import machinery in mitochondria.
References
Neupert, W. & Herrmann, J. M. Annu. Rev. Biochem. 76, 723–749 (2007).
Chacinska, A., Koehler, C. M., Milenkovic, D., Lithgow, T. & Pfanner, N. Cell 138, 628–644 (2009).
Marom, M., Azem, A. & Mokranjac, D. Biochim. Biophys. Acta (BBA) Biomembr. 1808, 990–1001 (2011).
Schulz, C., Schendzielorz, A. & Rehling, P. Trends Cell Biol. 25, 265–275 (2015).
Araiso, Y., Imai, K. & Endo, T. Annu. Rev. Biochem. 91, 679–703 (2022).
Sim, S. I., Chen, Y., Lynch, D. L., Gumbart, J. C. & Park, E. Nature 621, 620–626 (2023).
Fielden, L. F. et al. Nature 621, 627–634 (2023).
Zhou, X. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01103-7 (2023).
Araiso, Y. et al. Nature 575, 395–401 (2019).
Jumper, J. et al. Nature 596, 583–589 (2021).
Chacinska, A. et al. Cell 120, 817–829 (2005).
Ieva, R. et al. Mol. Cell 56, 641–652 (2014).
Lee, S. et al. FEBS Lett. 594, 1081–1087 (2020).
Schendzielorz, A. B. et al. J. Cell Biol. 216, 83–92 (2017).
Acknowledgements
This work was funded by the National Science Centre, Poland (grants 2019/35/B/NZ3/04066 and 2019/35/B/NZ3/04095).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Wasilewski, M., Draczkowski, P. & Chacinska, A. Protein import into mitochondria — a new path through the membranes. Nat Struct Mol Biol 30, 1831–1833 (2023). https://doi.org/10.1038/s41594-023-01170-w
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41594-023-01170-w
- Springer Nature America, Inc.