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Ferroptosis

FSP1 inhibition: pick your pocket

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From Nature Structural & Molecular Biology

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Ferroptosis suppressor protein 1 (FSP1, or AIFM2), an NADPH quinone reductase noted to protect cancer cells from ferroptosis, acts in FAD/NADPH binding and proton transfer. Recent papers assess its evolutionarily conserved sites via mutagenesis and define its inhibition as an off-target mediator of brequinar-mediated ferroptosis sensitization.

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Fig. 1: Schematic of FSP1 inhibitor modes-of-action.

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Acknowledgements

S.v.K. receives funding from collaborative research center grants (SFB1403, ID 414786233; SFB1530, ID 455784452; SFB1399, ID 413326622 and SFB1310, ID 325931972), through a priority program on ferroptosis (SPP2306, ID 461704389) all funded by the German Research Foundation (Deutsche Forschungsgesellschaft, DFG), and via CANTAR, which is funded through the program Netzwerke 2021, an initiative of the Ministry of Culture and Science of the State of Northrhine Westphalia, Germany.

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Authors and Affiliations

  1. University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany

    Christina M. Bebber & Silvia von Karstedt

  2. CECAD Cluster of Excellence, University of Cologne, Cologne, Germany

    Christina M. Bebber & Silvia von Karstedt

  3. University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany

    Silvia von Karstedt

Authors
  1. Christina M. Bebber
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  2. Silvia von Karstedt
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Correspondence to Silvia von Karstedt.

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The authors declare no competing interests.

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Bebber, C.M., von Karstedt, S. FSP1 inhibition: pick your pocket. Nat Struct Mol Biol 30, 1618–1619 (2023). https://doi.org/10.1038/s41594-023-01145-x

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