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Phospholipid synthesis

Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1

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New cryo-electron microscopy (cryo-EM) structures of CDP- and CDP-choline-bound choline phosphotransferase 1 (CHPT1) and choline/ethanolamine phosphotransferase 1 (CEPT1), involved in the metabolism of the two main lipids in eukaryotic cell membranes, capture the membrane proteins at resolution <4 Å, sufficient to gain mechanistic insights into these enzymes.

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Fig. 1: CHPT and CEPT in the context of lipid biosynthesis, the reaction catalyzed by them and their internal symmetry.
Fig. 2: Structural basis of substrate interactions and catalysis by CEPTs.

References

  1. Harayama, T. & Riezman, H. Nat. Rev. Mol. Cell Biol. 19, 281–296 (2018).

    Article  CAS  PubMed  Google Scholar 

  2. van Meer, G., Voelker, D. R. & Feigenson, G. W. Nat. Rev. Mol. Cell Biol. 9, 112–124 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kennedy, E. P. & Weiss, S. B. J. Biol. Chem. 222, 193–214 (1956).

    Article  CAS  PubMed  Google Scholar 

  4. Gibellini, F. & Smith, T. K. IUBMB Life 62, 414–28 (2010).

    Article  CAS  PubMed  Google Scholar 

  5. Wang, L. & Zhou, M. Nat. Commun. 14, 2753 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Wang, Z., Yang, M., Yang, Y., He, Y. & Qian, H. Nat. Commun. 14, 2529 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lopez-Lara, I. M. & Geiger, O. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1862, 1287–1299 (2017).

    Article  CAS  PubMed  Google Scholar 

  8. Yang, Y., Lee, M. & Fairn, G. D. J. Biol. Chem. 293, 6230–6240 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Sciara, G. et al. Nat. Commun. 5, 4068 (2014).

    Article  CAS  PubMed  Google Scholar 

  10. Nogly, P. et al. Nat. Commun. 5, 4169 (2014).

    Article  CAS  PubMed  Google Scholar 

  11. Aleksandrova, A. A., Sarti, E. & Forrest, L. R. J. Mol. Biol. 432, 597–604 (2020).

    Article  CAS  PubMed  Google Scholar 

  12. Clarke, O. B. et al. Nat. Commun. 6, 8505 (2015).

    Article  PubMed  Google Scholar 

  13. Yang, B. W., Yao, H. B., Li, D. F. & Liu, Z. F. Curr. Res. Struct. Biol. 3, 312–323 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Jumper, J. et al. Nature 596, 583–589 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Section on Structural and Chemical Biology, Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    Rahul Raina & Anirban Banerjee

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  1. Rahul Raina
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  2. Anirban Banerjee
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Correspondence to Anirban Banerjee.

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The authors declare no competing interests.

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Raina, R., Banerjee, A. Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1. Nat Struct Mol Biol 30, 1247–1250 (2023). https://doi.org/10.1038/s41594-023-01073-w

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