New cryo-electron microscopy (cryo-EM) structures of CDP- and CDP-choline-bound choline phosphotransferase 1 (CHPT1) and choline/ethanolamine phosphotransferase 1 (CEPT1), involved in the metabolism of the two main lipids in eukaryotic cell membranes, capture the membrane proteins at resolution <4 Å, sufficient to gain mechanistic insights into these enzymes.
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Raina, R., Banerjee, A. Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1. Nat Struct Mol Biol 30, 1247–1250 (2023). https://doi.org/10.1038/s41594-023-01073-w
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DOI: https://doi.org/10.1038/s41594-023-01073-w
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