Skip to main content
SpringerLink
Log in

Dosage compensation

Transcription and replication meet the silent X chromosome territory

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

Inactivation of one of the two female X chromosomes involves condensing it into a repressive subnuclear territory, which is depleted of transcriptional components and undergoes late-stage DNA replication. Two new studies unravel how compartmentalization of the inactive mammalian X chromosome affects transcription and DNA replication.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Compartmentalization of the X chromosome in the nucleus.

References

  1. Okamoto, I., Otte, A. P., Allis, C. D., Reinberg, D. & Heard, E. Science 303, 644–649 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Takagi, N., Sugawara, O. & Sasaki, M. Chromosoma 85, 275–286 (1982).

    Article  CAS  PubMed  Google Scholar 

  3. Markaki, Y. et al. Cell 184, 6174–6192.e32 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Giorgetti, L. et al. Cell 157, 950–963 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Collombet, S. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01008-5 (2023).

    Article  PubMed  Google Scholar 

  6. Poonperm, R. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01052-1 (2023).

    Article  PubMed  Google Scholar 

  7. Jansz, N. et al. Nat. Struct. Mol. Biol. 25, 766–777 (2018).

    Article  CAS  PubMed  Google Scholar 

  8. Goronzy, I. N. et al. Cell Rep. 41, 111730 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Jachowicz, J. W. et al. Nat. Genet. 49, 1502–1510 (2017).

    Article  CAS  PubMed  Google Scholar 

  10. Crane, E. et al. Nature 523, 240–244 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Renschler, G. et al. Genes Dev. 33, 1591–1612 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Anderson, E. C. et al. Dev. Cell 51, 192–207.e6 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Molecular Biology (IMB), Mainz, Germany

    Frederic Zimmer & Claudia Isabelle Keller Valsecchi

  2. DFG-Research Training Group 2526 ‘GenEvo’, Mainz, Germany

    Frederic Zimmer

  3. Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

    M. Felicia Basilicata

Authors
  1. Frederic Zimmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Felicia Basilicata
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Claudia Isabelle Keller Valsecchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Claudia Isabelle Keller Valsecchi.

Ethics declarations

Competing interests

The authors declare no competing interests

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zimmer, F., Basilicata, M.F. & Keller Valsecchi, C.I. Transcription and replication meet the silent X chromosome territory. Nat Struct Mol Biol 30, 1054–1056 (2023). https://doi.org/10.1038/s41594-023-01054-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-023-01054-z

  • Springer Nature America, Inc.

Search

Navigation