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Structural insights into drug interaction of polyspecific organic cation transporters

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Cryo-electron microscopy (EM) structures and molecular dynamics simulations of organic cation transporters (OCTs) in ligand-free and drug-bound states provide insights into drug recognition by OCTs. As OCTs are largely responsible for the hepatic uptake and renal clearance of hundreds of drugs, these results will help to inform future drug design and development efforts.

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Fig. 1: Structure and ligand recognition mechanisms of OCTs.

References

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This is a summary of: Suo, Y. et al. Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01017-4 (2023).

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Structural insights into drug interaction of polyspecific organic cation transporters. Nat Struct Mol Biol 30, 874–875 (2023). https://doi.org/10.1038/s41594-023-01018-3

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  • DOI: https://doi.org/10.1038/s41594-023-01018-3

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