The correction of errors during mitochondrial DNA replication by the proofreading function of DNA polymerase-γ is crucial for maintaining the integrity of the mitochondrial genome and the production of cellular energy. Using cryo-electron microscopy, several steps of the DNA polymerase-γ proofreading pathway have been revealed at near-atomic resolution.
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References
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This is a summary of: Park, J. et al. Polγ coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-00980-2 (2023).
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A look into the dynamic process of proofreading in DNA polymerase-γ at near-atomic resolution. Nat Struct Mol Biol 30, 722–723 (2023). https://doi.org/10.1038/s41594-023-01001-y
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DOI: https://doi.org/10.1038/s41594-023-01001-y
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