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Chromatin, stacked at the centromere

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Cryo-EM analysis reveals the mechanism by which chromatin is compacted at the centromere by the H3 histone variant CENP-N. Intriguingly, despite the structural differences between CENP-N and linker H1 histones, both appear to similarly compact higher-order nucleosome structures.

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Fig. 1: Fundamental conformational differences between canonical chromatin and centromeric chromatin.

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Authors and Affiliations

  1. Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada

    Katrina V. Good & Juan Ausió

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  1. Katrina V. Good
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  2. Juan Ausió
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Correspondence to Katrina V. Good or Juan Ausió.

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The authors declare no competing interests.

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Good, K.V., Ausió, J. Chromatin, stacked at the centromere. Nat Struct Mol Biol 29, 288–290 (2022). https://doi.org/10.1038/s41594-022-00759-x

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