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DNA DAMAGE REPAIR

Is it a wrap? Nucleosome interactions of the BRCA1-binding partner, BARD1, steal the scene

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Emerging findings provide compelling evidence that the BRCA1-binding partner BARD1 contributes yet further to BRCA1 function. BARD1 is crucial for positioning the E2 ubiquitin-conjugating enzyme that confers specificity of its ligase to residues on histone H2A, and BARD1 also promotes DNA damage–induced chromatin recruitment through an interaction with ubiquitin-conjugated Lys13 or Lys15 of H2A on the nucleosome core particle.

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Fig. 1: Nucleosome interactions of BARD1.

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Acknowledgements

I thank the University of Birmingham.

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  1. Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

    Joanna R. Morris

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  1. Joanna R. Morris
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Correspondence to Joanna R. Morris.

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Morris, J.R. Is it a wrap? Nucleosome interactions of the BRCA1-binding partner, BARD1, steal the scene. Nat Struct Mol Biol 28, 708–710 (2021). https://doi.org/10.1038/s41594-021-00658-7

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