The folding of ribosomal RNAs is central to the biogenesis of the mitoribosome and is a complex, stepwise process. Five recent cryo-EM studies detail the late steps of the folding and maturation of the human mitoribosomal large subunit RNA that forms the catalytic core of the ribosome: the peptidyl transferase center (PTC).
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Sissler, M., Hashem, Y. Mitoribosome assembly comes into view. Nat Struct Mol Biol 28, 631–633 (2021). https://doi.org/10.1038/s41594-021-00640-3
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DOI: https://doi.org/10.1038/s41594-021-00640-3
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