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GENE SILENCING

New players on the piRNA field

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The nuclear piRNA pathway safeguards genome integrity in the germline by silencing transposable elements. Three recent studies have identified new players in the mammalian pathway. Two of these, TEX15 and SPOCD1, might provide a link between piRNA-guided complexes that recognize genomic targets and the molecular machinery that induces DNA methylation and transcriptional repression during mouse spermatogenesis.

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Fig. 1: Comparison of piRNA-mediated transcriptional silencing in Drosophila and mice.

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Authors and Affiliations

  1. California Institute of Technology, Division of Biology and Biological Engineering, Pasadena, CA, USA

    Maria Ninova & Katalin Fejes Tóth

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  1. Maria Ninova
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  2. Katalin Fejes Tóth
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Correspondence to Katalin Fejes Tóth.

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The authors declare no competing interests.

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Ninova, M., Fejes Tóth, K. New players on the piRNA field. Nat Struct Mol Biol 27, 777–779 (2020). https://doi.org/10.1038/s41594-020-0484-7

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