In situ structures of the spirochete flagellar motor by cryo-ET reveal two distinct modes of interactions between the rotor ring and stator units. Together with new cryo-EM structures of the isolated stator units, this work provides insights into the mechanisms of torque generation and directional switch.
This is a preview of subscription content, log in via an institution to check access.
References
Minamino, T. & Namba, K. J. Mol. Microbiol. Biotechnol. 7, 5–17 (2004).
Nakamura, S. & Minamino, T. Biomolecules 9, 279 (2019).
Berg, H. C. Annu. Rev. Biochem. 72, 19–54 (2003).
Magariyama, Y. et al. Nature 371, 752 (1994).
Fujii, T. et al. Nat. Commun. 8, 14276 (2017).
Minamino, T., Terahara, N., Kojima, S. & Namba, K. Mol. Microbiol. 109, 723–734 (2018).
Thomas, D., Francis, N. R., Xu, C. & DeRosier, D. J. J. Bacteriol. 188, 7039–7048 (2006).
Kawamoto, A. et al. Sci. Rep. 3, 3369 (2013).
Chang, Y. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-020-0497-2 (2020)
Deme, J. C. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-020-0788-8 (2020).
Santiveri, M. et al. Cell https://doi.org/10.1016/j.cell.2020.08.016 (2020).
Thomas, D. R., Morgan, D. G. & DeRosier, D. J. Proc. Natl Acad. Sci. USA 96, 10134–10139 (1999).
Sakai, T. et al. Mbio 10, e00079–19 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Namba, K. A proposed gear mechanism for torque generation in the flagellar motor. Nat Struct Mol Biol 27, 1004–1006 (2020). https://doi.org/10.1038/s41594-020-00514-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41594-020-00514-0
- Springer Nature America, Inc.