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VIROLOGY

Reoviridae transcription is more than an open-and-shut case

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Segmented, double-stranded RNA viruses of the Reoviridae family tightly regulate the activity of encapsidated polymerases to mediate the transition between genome replication and iterative rounds of multipartite transcription within a particle. By resolving multiple in situ structures of the transcribing complex, a new study reveals enzyme conformational changes and RNA trajectories during specific transcriptional states that support an ‘ouroboros’ model of conservative transcription for a member of the Reoviridae family.

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Fig. 1: RdRp conformational changes and surface charges mediating state changes and RNA dynamics during CPV transcription.

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Authors and Affiliations

  1. Department of Pediatrics and Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

    Kristen Ogden

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  1. Kristen Ogden
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Correspondence to Kristen Ogden.

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The author declares no competing interests.

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Ogden, K. Reoviridae transcription is more than an open-and-shut case. Nat Struct Mol Biol 26, 991–993 (2019). https://doi.org/10.1038/s41594-019-0328-5

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