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BACTERIAL FLAGELLUM

Hooked on motility

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A new cryo-EM structure of the bacterial flagellar hook, which connects the motor to the flagellar filament, reveals 11 distinctive conformations of the subunit. The cooperative dynamic switching among these states offers a dramatic extension of two-state models of protein allostery.

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Fig. 1: A view down the curved lumen of the supercoiled flagellar hook.

References

  1. Berg, H. C. & Anderson, R. A. Nature 245, 380–382 (1973).

    Article  CAS  Google Scholar 

  2. Wemmer, K. A. & Marshall, W. F. Curr. Biol. 14, R992–R993 (2004).

    Article  CAS  Google Scholar 

  3. Shibata, S.M., Matsunami, H., Aizawa, S.-I. & Wolf, M. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-019-0301-3 (2019).

  4. Oosawa, F. & Asakura, S. Thermodynamics of the Polymerization of Protein (Academic Press, 1975).

  5. Hyman, H. C. & Trachtenberg, S. J. Mol. Biol. 220, 79–88 (1991).

    Article  CAS  Google Scholar 

  6. Asakura, S. Adv. Biophys. 1, 99–155 (1970).

    CAS  PubMed  Google Scholar 

  7. Calladine, C. R. Nature 255, 121–124 (1975).

    Article  CAS  Google Scholar 

  8. Yamashita, I. et al. Nat. Struct. Biol. 5, 125–132 (1998).

    Article  CAS  Google Scholar 

  9. Samatey, F. A. et al. Nature 410, 331–337 (2001).

    Article  CAS  Google Scholar 

  10. Maki-Yonekura, S., Yonekura, K. & Namba, K. Nat. Struct. Mol. Biol. 17, 417–422 (2010).

    Article  CAS  Google Scholar 

  11. Wang, F. et al. Nat Commun 8, 960 (2017).

    Article  Google Scholar 

  12. Samatey, F. A. et al. Nature 431, 1062–1068 (2004).

    Article  CAS  Google Scholar 

  13. Shaikh, T. R. et al. Proc. Natl Acad. Sci. USA 102, 1023–1028 (2005).

    Article  CAS  Google Scholar 

  14. Shibata, S. et al. Mol. Microbiol. 64, 1404–1415 (2007).

    Article  CAS  Google Scholar 

  15. Matsunami, H., Barker, C. S., Yoon, Y. H., Wolf, M. & Samatey, F. A. Nat. Commun. 7, 13425 (2016).

    Article  CAS  Google Scholar 

  16. Fujii, T., Matsunami, H., Inoue, Y. & Namba, K. Biophys. Physicobiol. 15, 28–32 (2018).

    Article  CAS  Google Scholar 

  17. Kato, S., Okamoto, M. & Asakura, S. J. Mol. Biol. 173, 463–76 (1984).

    Article  CAS  Google Scholar 

  18. Subramaniam, S., Earl, L. A., Falconieri, V., Milne, J. L. & Egelman, E. H. Curr. Opin. Struct. Biol. 41, 194–202 (2016).

    Article  CAS  Google Scholar 

  19. Yoshioka, K., Aizawa, S. & Yamaguchi, S. J. Bacteriol. 177, 1090–1093 (1995).

    Article  CAS  Google Scholar 

  20. Kato, T. et al. bioRxiv https://doi.org/10.1101/748384 (2019).

Download references

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA

    Edward H. Egelman

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  1. Edward H. Egelman
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Correspondence to Edward H. Egelman.

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Egelman, E.H. Hooked on motility. Nat Struct Mol Biol 26, 848–849 (2019). https://doi.org/10.1038/s41594-019-0302-2

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