Skip to main content
Log in

AUTOPHAGY

Crisis management by autophagy

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

Autophagy is a highly contextual modulator of tumorigenesis. A new study shows that autophagy can serve as a tumor suppressor to mediate cell death at replicative crisis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Two-stage immortalization and autophagy.

References

  1. White, E., Mehnert, J. M. & Chan, C. S. Clin. Cancer Res. 21, 5037–5046 (2015).

    Article  CAS  Google Scholar 

  2. Nassour, J. et al. Nature https://www.nature.com/articles/s41586-019-0885-0 (2019).

  3. Wright, W. E. & Shay, J. W. Exp. Gerontol. 27, 383–389 (1992).

    Article  CAS  Google Scholar 

  4. Cesare, A. J. & Karlseder, J. Curr. Opin. Cell Biol. 24, 731–738 (2012).

    Article  CAS  Google Scholar 

  5. Fumagalli, M. et al. Nat. Cell Biol. 14, 355–365 (2012).

    Article  CAS  Google Scholar 

  6. Hewitt, G. et al. Nat. Commun. 3, 708 (2012).

    Article  Google Scholar 

  7. Maciejowski, J. & de Lange, T. Nat. Rev. Mol. Cell Biol. 18, 175–186 (2017).

    Article  CAS  Google Scholar 

  8. Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).

    Article  CAS  Google Scholar 

  9. Li, T. & Chen, Z. J. J. Exp. Med. 215, 1287–1299 (2018).

    Article  CAS  Google Scholar 

  10. Watson, R. O., Manzanillo, P. S. & Cox, J. S. Cell 150, 803–815 (2012).

    Article  CAS  Google Scholar 

  11. Liang, Q. et al. Cell Host Microbe 15, 228–238 (2014).

    Article  CAS  Google Scholar 

  12. Ivanov, A. et al. J. Cell Biol. 202, 129–143 (2013).

    Article  CAS  Google Scholar 

  13. Dou, Z. et al. Nature 527, 105–109 (2015).

    Article  CAS  Google Scholar 

  14. Doherty, J. & Baehrecke, E. H. Nat. Cell Biol. 20, 1110–1117 (2018).

    Article  CAS  Google Scholar 

  15. Cuervo, A. M. Trends Genet. 24, 604–612 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Masashi Narita.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Narita, M. Crisis management by autophagy. Nat Struct Mol Biol 26, 151–152 (2019). https://doi.org/10.1038/s41594-019-0195-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-019-0195-0

  • Springer Nature America, Inc.

Navigation