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Synapses shape oligodendrocyte precursor cell development and predict myelination location

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Using in vivo imaging in zebrafish, we unveiled critical components (PSD-95, gephyrin and neuroligin-3) and dynamic properties of synapses between neurons and oligodendrocyte precursor cells (OPC). Furthermore, we showed that neuron–OPC synapses have a pivotal role in regulating OPC development and CNS myelination.

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Fig. 1: Neuron–OPC synapses have a role in OPC development and predict myelination location.

References

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This is a summary of: Li, J., Miramontes, T. G., Czopka, T. & Monk, K. R. Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01553-8 (2024).

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Synapses shape oligodendrocyte precursor cell development and predict myelination location. Nat Neurosci 27, 217–218 (2024). https://doi.org/10.1038/s41593-023-01555-6

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  • DOI: https://doi.org/10.1038/s41593-023-01555-6

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