We show that genetic disruption of TFEB- and vacuolar ATPase-mediated lysosomal signaling leads to increased tau pathology and defective microglia activation. Our findings demonstrate an essential role of the lysosome in regulating microglia activity in tauopathy and Alzheimer’s disease.
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This is a summary of: Wang, B. et al. TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01494-2 (2023).
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Lysosome regulation of microglia in Alzheimer’s disease via TFEB–vacuolar ATPase. Nat Neurosci 27, 13–14 (2024). https://doi.org/10.1038/s41593-023-01495-1
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DOI: https://doi.org/10.1038/s41593-023-01495-1
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