We developed a 3D human neuroimmune axis model to study the interplay of brain innate immune cells and peripheral adaptive immune cells in Alzheimer’s disease. Alzheimer’s disease pathology induced a marked increase in CD8+ T cell infiltration, exacerbating neurodegeneration. The CXCL10–CXCR3 pathway has a key role in mediating this process.
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References
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This is a summary of: Jorfi, M. et al. Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01415-3 (2023)
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T cell–microglia signaling exacerbates neuropathology in an Alzheimer’s disease model. Nat Neurosci 26, 1487–1488 (2023). https://doi.org/10.1038/s41593-023-01417-1
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DOI: https://doi.org/10.1038/s41593-023-01417-1
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