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Abnormal lipid metabolism shapes astrocyte reactivity in patients with epilepsy

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In the brains of patients with epilepsy, apolipoprotein E-mediated lipid transfer from hyperactive neurons to astrocytes results in lipid metabolism reprogramming and formation of lipid-accumulated reactive astrocytes. These astrocytes exacerbate abnormal discharges of neighboring neurons and, in mice, aggravate seizure symptoms, leading to disease progression.

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Fig. 1: LARAs promote neuronal excitability in mouse models of epilepsy via the A2AR.

References

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This is a summary of: Chen, Z.-P. et al. Lipid-accumulated reactive astrocytes promote disease progression in epilepsy. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01288-6 (2023).

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Abnormal lipid metabolism shapes astrocyte reactivity in patients with epilepsy. Nat Neurosci 26, 535–536 (2023). https://doi.org/10.1038/s41593-023-01298-4

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  • DOI: https://doi.org/10.1038/s41593-023-01298-4

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