How genetic and environmental risk factors interact to trigger the development of post-traumatic stress disorder (PTSD) remains largely unknown. Seah et al. model stress hypersensitivity as a potential mechanism by examining transcriptomic responses to glucocorticoids in neurons derived from individuals with PTSD.
References
Seriès, P. Nat. Neurosci. 22, 334–336 (2019).
Gelernter, J. et al. Nat. Neurosci. 22, 1394–1401 (2019).
Seah, C. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01161-y (2022).
Breen, M. S. et al. Transl. Psychiatry 9, 201 (2019).
Popoli, M., Yan, Z., McEwen, B. S. & Sanacora, G. Nat. Rev. Neurosci. 13, 22–37 (2011).
Zhang, Y. et al. Neuron 78, 785–798 (2013).
Zhang, S. et al. Science 369, 561–565 (2020).
Schrode, N. et al. Nat. Genet. 51, 1475–1485 (2019).
Ramos-Rodríguez, M. et al. Nat. Genet. 51, 1588–1595 (2019).
Duan, J. et al. Transl. Psychiatry 8, 158 (2018).
Boulting, G. L. et al. Nat. Neurosci. 24, 437–448 (2021).
Doostparast Torshizi, A. et al. Sci. Adv. 5, eaau4139 (2019).
Matosin, N., Halldorsdottir, T. & Binder, E. B. Biol. Psychiatry 83, 821–830 (2018).
Kwon, D. Y. et al. Nat. Commun. 13, 55 (2022).
Replogle, J. M. et al. Cell 185, 2559–2575.e28 (2022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Zhang, S., Sanders, A.R. & Duan, J. Modeling PTSD neuronal stress responses in a dish. Nat Neurosci 25, 1402–1404 (2022). https://doi.org/10.1038/s41593-022-01172-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-022-01172-9
- Springer Nature America, Inc.