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Impaired gut barrier affects microglia health

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As researchers uncover new roles for the microbiome in health and disease, recent studies have emerged linking the microbiome to aspects of aging. Mossad and colleagues demonstrate that a microbiome-mediated disruption of the intestinal barrier, associated with aging, can contribute to dysfunction of microglia in mice.

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Fig. 1: Increased intestinal permeability with age facilitates the translocation and accumulation of metabolites that promote microglia dysfunction.

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Authors and Affiliations

  1. Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA

    John W. Bostick & Sarkis K. Mazmanian

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  1. John W. Bostick
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  2. Sarkis K. Mazmanian
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Correspondence to Sarkis K. Mazmanian.

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Bostick, J.W., Mazmanian, S.K. Impaired gut barrier affects microglia health. Nat Neurosci 25, 268–270 (2022). https://doi.org/10.1038/s41593-022-01028-2

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