Positive and negative valence are encoded in specific neural populations of the basolateral amygdala, but only few of these populations have been characterized. A new study identifies a novel population, defined by the molecular marker Fezf2, and demonstrates that two of its output pathways differentially encode emotional valence.
References
Lange, C. G., & James, W. The Emotions Vol. 1, 135 (Williams & Wilkins Co, 1922); https://doi.org/10.1037/10735-000
Pignatelli, M. & Beyeler, A. Curr. Opin. Behav. Sci. 26, 97–106 (2019).
Zhang, X., Guan, W., Yang, T. & Li, B. Nat. Neurosci. https://doi.org/10.1038/s41593-021-00927-0 (2021).
Kim, J., Pignatelli, M., Xu, S., Itohara, S. & Tonegawa, S. Nat. Neurosci. 19, 1636–1646 (2016).
Beyeler, A. et al. Neuron 90, 348–361 (2016).
O’Neill, P.-K., Gore, F. & Salzman, C. D. Curr. Opin. Neurobiol. 49, 175–183 (2018).
Beyeler, A. et al. Cell Rep. 22, 905–918 (2018).
Namburi, P. et al. Nature 520, 675–678 (2015).
Stuber, G. D. et al. Nature 475, 377–380 (2011).
Zhang, X., Kim, J. & Tonegawa, S. Neuron 105, 1077–1093.e7 (2020).
Shen, C.-J. et al. Nat. Med. 25, 337–349 (2019).
Lodato, S. et al. Nat. Neurosci. 17, 1046–1054 (2014).
Zuccotti, A., Magueresse, C. L., Chen, M., Neitz, A. & Monyer, H. Proc. Natl Acad. Sci. USA 111, 10726–10731 (2014).
Felix-Ortiz, A. C. et al. Neuron 79, 658–664 (2013).
Daviu, N., Bruchas, M. R., Moghaddam, B., Sandi, C. & Beyeler, A. Neurobiol. Stress 11, 100191 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Ju, A., Beyeler, A. A new player in neural circuits of emotions. Nat Neurosci 24, 1506–1507 (2021). https://doi.org/10.1038/s41593-021-00945-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-021-00945-y
- Springer Nature America, Inc.