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MeCP2 for sustained antidepressant effects

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Ketamine has transformed the treatment of depression by providing rapid relief from depressive symptoms, but the mechanisms mediating its long-term effects are unclear. Kim et al. show that MeCP2 signaling in the hippocampus is critical for supporting sustained antidepressant effects.

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Fig. 1: A molecular mechanism supporting sustained antidepressant effects.

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Authors and Affiliations

  1. Department of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA

    Shane Johnson & Conor Liston

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  1. Shane Johnson
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  2. Conor Liston
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Correspondence to Conor Liston.

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The authors declare no competing interests.

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Johnson, S., Liston, C. MeCP2 for sustained antidepressant effects. Nat Neurosci 24, 1047–1048 (2021). https://doi.org/10.1038/s41593-021-00881-x

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