Hardening of the arteries (atherosclerosis) was linked to dementia long ago, but subsequently, Alzheimer’s plaques and tangles have received more attention. A new proteome-wide association study unveils molecular links between intracranial atherosclerosis and dementia, independent of other pathologies, providing new evidence for one of the oldest suspected causes of dementia.
References
World Health Organization. Dementia. WHO http://www.who.int/en/news-room/fact-sheets/detail/dementia. (Accessed 18 March 2020).
Hachinski, V. et al. Alzheimers Dement. 15, 961–984 (2019).
Iadecola, C. & Gottesman, R. F. Circ. Res. 123, 406–408 (2018).
Iadecola, C. et al. J. Am. Coll. Cardiol. 73, 3326–3344 (2019).
Iturria-Medina, Y., Sotero, R. C., Toussaint, P. J., Mateos-Pérez, J. M. & Evans, A. C. Nat. Commun. 7, 11934 (2016).
Wingo, A. P. Nat. Neurosci. https://doi.org/10.1038/s41593-020-0635-5 (2020).
Preische, O. et al. Nat. Med. 25, 277–283 (2019).
Roher, A. E. et al. Arterioscler. Thromb. Vasc. Biol. 23, 2055–2062 (2003).
Gottesman, R. F. et al. JAMA Neurol. 77, 350–357 (2020).
Gustavsson, A.-M. et al. Ann. Neurol. 87, 52–62 (2020).
Iadecola, C. Neuron 96, 17–42 (2017).
Tan, C. et al. Neuron 101, 920–937.e13 (2019).
Faraco, G. et al. Nature 574, 686–690 (2019).
Iadecola, C. & Gottesman, R. F. Circ. Res. 124, 1025–1044 (2019).
Kivipelto, M., Mangialasche, F. & Ngandu, T. Nat. Rev. Neurol. 14, 653–666 (2018).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Iadecola, C. Revisiting atherosclerosis and dementia. Nat Neurosci 23, 691–692 (2020). https://doi.org/10.1038/s41593-020-0626-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-020-0626-6
- Springer Nature America, Inc.