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Inflammation stresses out brain development

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A new study reveals that maternal immune activation promotes sex-biased activation of the integrated stress response in the developing mouse brain and that this mechanistically contributes to the onset of autism-related behaviors uniquely in male offspring.

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Fig. 1: The integrated stress response contributes to maternal immune activation (MIA)-induced neurodevelopmental changes.

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Authors and Affiliations

  1. Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, Virginia, USA

    Kristine E. Zengeler & John R. Lukens

  2. Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia, USA

    Kristine E. Zengeler & John R. Lukens

  3. Cell and Molecular Biology Training Program, School of Medicine, University of Virginia, Charlottesville, Virginia, USA

    Kristine E. Zengeler & John R. Lukens

Authors
  1. Kristine E. Zengeler
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  2. John R. Lukens
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Corresponding authors

Correspondence to Kristine E. Zengeler or John R. Lukens.

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The authors declare no competing interests.

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Zengeler, K.E., Lukens, J.R. Inflammation stresses out brain development. Nat Neurosci 24, 155–157 (2021). https://doi.org/10.1038/s41593-020-00775-4

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