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Norepinephrine as a modulator of microglial dynamics

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Two new studies demonstrate the importance of awake imaging to investigate microglia–neuron interactions. These studies show that microglial dynamics are influenced by neuronal activity, and they provide evidence that norepinergic signaling plays an important role in this effect.

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Fig. 1: Schematic illustration of changes of microglial dynamics in awake and anesthetized mice.

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Acknowledgements

This work was supported by SFB 1089‚ Synaptic Micronetworks in Health and Disease. Thanks to R. McManus for proofreading the article.

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Authors and Affiliations

  1. Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, Bonn, Germany

    Dilek Mercan & Michael T. Heneka

  2. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

    Michael T. Heneka

  3. Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA

    Michael T. Heneka

Authors
  1. Dilek Mercan
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  2. Michael T. Heneka
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Correspondence to Michael T. Heneka.

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Mercan, D., Heneka, M.T. Norepinephrine as a modulator of microglial dynamics. Nat Neurosci 22, 1745–1746 (2019). https://doi.org/10.1038/s41593-019-0526-9

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