Skip to main content
SpringerLink
Log in

NEURAL CIRCUITS

Guardians of the learning gate

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

Unexpected experiences often lead to strong memories. A new study by Krabbe and Paradiso et al. shows that vasoactive intestinal peptide (VIP)-expressing interneurons of the basolateral amygdala control associative learning and memory formation by gating aversive stimuli scaled by their unexpectedness.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: VIP interneurons act as a permissive gate on local BLA circuitry during associative fear learning.

References

  1. LeDoux, J. E. Annu. Rev. Neurosci. 23, 155–184 (2000).

    Article  CAS  Google Scholar 

  2. Krabbe, S. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-019-0508-y (2019)

  3. Acsády, L., Görcs, T. J. & Freund, T. F. Neuroscience 73, 317–334 (1996).

    Article  Google Scholar 

  4. Hajos, N., Acsady, L. & Freund, T. F. Eur. J. Neurosci. 8, 1415–1431 (1996).

    Article  CAS  Google Scholar 

  5. Lee, S., Kruglikov, I., Huang, Z. J., Fishell, G. & Rudy, B. Nat. Neurosci. 16, 1662–1670 (2013).

    Article  CAS  Google Scholar 

  6. Pi, H.-J. et al. Nature 503, 521–524 (2013).

    Article  CAS  Google Scholar 

  7. Pfeffer, C. K., Xue, M., He, M., Huang, Z. J. & Scanziani, M. Nat. Neurosci. 16, 1068–1076 (2013).

    Article  CAS  Google Scholar 

  8. Rhomberg, T. et al. J. Neurosci. 38, 6983–7003 (2018).

    Article  CAS  Google Scholar 

  9. Hangya, B., Ranade, S. P., Lorenc, M. & Kepecs, A. Cell 162, 1155–1168 (2015).

    Article  CAS  Google Scholar 

  10. Lin, S.-C. & Nicolelis, M. A. Neuron 59, 138–149 (2008).

    Article  CAS  Google Scholar 

  11. Richard, J. M., Ambroggi, F., Janak, P. H. & Fields, H. L. Neuron 90, 1165–1173 (2016).

    Article  CAS  Google Scholar 

  12. Hangya, B., Pi, H.-J., Kvitsiani, D., Ranade, S. P. & Kepecs, A. Curr. Opin. Neurobiol. 26, 117–124 (2014).

    Article  CAS  Google Scholar 

  13. Fu, Y. et al. Cell 156, 1139–1152 (2014).

    Article  CAS  Google Scholar 

  14. Turi, G. F. et al. Neuron 101, 1150–1165.e8 (2019).

    Article  CAS  Google Scholar 

  15. Gulyás, A. I., Hájos, N. & Freund, T. F. J. Neurosci. 16, 3397–3411 (1996).

    Article  Google Scholar 

Download references

Acknowledgements

We thank L. Acsády for insightful comments on the manuscript. This work was supported by the ‘Lendület’ Program of the Hungarian Academy of Sciences (LP2015-2/2015), NKFIH KH125294, and the European Research Council Starting Grant no. 715043.

Author information

Authors and Affiliations

  1. Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

    Panna Hegedüs, Sergio Martínez-Bellver & Balázs Hangya

  2. János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary

    Panna Hegedüs

Authors
  1. Panna Hegedüs
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sergio Martínez-Bellver
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Balázs Hangya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Balázs Hangya.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hegedüs, P., Martínez-Bellver, S. & Hangya, B. Guardians of the learning gate. Nat Neurosci 22, 1747–1748 (2019). https://doi.org/10.1038/s41593-019-0519-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41593-019-0519-8

  • Springer Nature America, Inc.

Search

Navigation