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A common ground for pain and depression

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Chronic pain is associated with anxio-depressive comorbidities, but the neuroanatomical substrates remain unknown. A specific serotonergic pathway from the dorsal raphe nucleus to the lateral habenula via the central amygdala is now uncovered as a key neural circuit governing comorbid depressive symptoms in chronic pain.

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Fig. 1: A proposed novel circuit underlying depressive-like behavior in chronic pain.

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Acknowledgements

The authors acknowledge funding from the Deutsche Forschungsgemeinschaft in form of grants in Collaborative Research Center 1158 to R.K. (projects B01 and B06) and to A.T.T. (project S01).

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Authors and Affiliations

  1. Pharmacology Institute, Heidelberg University, Heidelberg, Germany

    Anke Tappe-Theodor & Rohini Kuner

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  1. Anke Tappe-Theodor
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  2. Rohini Kuner
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Correspondence to Rohini Kuner.

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Tappe-Theodor, A., Kuner, R. A common ground for pain and depression. Nat Neurosci 22, 1612–1614 (2019). https://doi.org/10.1038/s41593-019-0499-8

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