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Sharpening the tools for pericyte research

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The creation of a murine Cre driver specific to CNS capillary pericytes has opened a major bottleneck in brain microvascular research. Using this tool, pericyte loss in the adult brain is shown to induce neuronal loss due to concurrent microcirculatory failure and depletion of the protective trophic factor pleiotrophin.

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Fig. 1: Selective ablation of capillary pericytes in the adult brain leads to concurrent microcirculatory failure and depletion of pleiotrophin levels.

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Authors and Affiliations

  1. Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Seattle, WA, USA

    Andrée-Anne Berthiaume & Andy Y. Shih

  2. Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA

    Andrée-Anne Berthiaume & Andy Y. Shih

Authors
  1. Andrée-Anne Berthiaume
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  2. Andy Y. Shih
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Correspondence to Andy Y. Shih.

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The authors declare no competing interests.

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Berthiaume, AA., Shih, A.Y. Sharpening the tools for pericyte research. Nat Neurosci 22, 1041–1043 (2019). https://doi.org/10.1038/s41593-019-0437-9

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