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HISTORICAL NEWS & VIEWS: SLEEP

Back to baseline: sleep recalibrates synapses

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In 2008, Vyazovskiy et al. published a seminal study demonstrating that sleep induces a widespread downscaling of synapses that counters the synaptic upscaling that occurred during prior wakefulness. The study laid the groundwork for current research into the ‘where’ and ‘when’ of homeostatic neuronal network regulation during sleep.

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Fig. 1: Simplified scheme of homeostatic synaptic downscaling and renormalization during sleep.

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Authors and Affiliations

  1. Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany

    Niels Niethard & Jan Born

  2. Center for Integrative Neuroscience, University of Tübingen, Tübingen, Germany

    Jan Born

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  1. Niels Niethard
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  2. Jan Born
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Correspondence to Niels Niethard or Jan Born.

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Niethard, N., Born, J. Back to baseline: sleep recalibrates synapses. Nat Neurosci 22, 149–151 (2019). https://doi.org/10.1038/s41593-018-0327-6

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