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HISTORICAL NEWS AND VIEWS: FEEDING BEHAVIOR

Dopamine and diet-induced obesity

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In 2010, Johnson and Kenny provided conclusive evidence that extended access to a Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors while promoting obesity. This focused attention on the parallels between drug addiction and overeating and fueled a decade of food addiction research.

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Fig. 1: Possible pathways from diet to dopamine adaptation.

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Authors and Affiliations

  1. Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA

    Alexandra G. DiFeliceantonio & Dana M. Small

  2. Modern Diet and PhysiologyResearch Center, YaleUniversity, New Haven, CT, USA

    Alexandra G. DiFeliceantonio & Dana M. Small

  3. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Alexandra G. DiFeliceantonio

  4. Department of Psychology, Yale University, New Haven, CT, USA

    Dana M. Small

Authors
  1. Alexandra G. DiFeliceantonio
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  2. Dana M. Small
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Correspondence to Dana M. Small.

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DiFeliceantonio, A.G., Small, D.M. Dopamine and diet-induced obesity. Nat Neurosci 22, 1–2 (2019). https://doi.org/10.1038/s41593-018-0304-0

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