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MICROGLIAL EPIGENETICS

The diverse culinary habits of microglia

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Heterogeneity of function in microglia from different brain regions is suspected but largely unknown. This paper identifies the epigenetic mechanism underlying differential phagocytic activity of microglia in discrete brain regions and examines the consequences of inducing an appetite not commensurate with the level of cell death in the region in which they reside.

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Fig. 1: Epigenetic programming of microglia in different brain regions maintains distinct levels of cell clearance.

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Authors and Affiliations

  1. Program in Neuroscience, Harvard Medical School, Lurie Center for Autism, Massachusetts General Hospital, Boston, Massachusetts, USA

    Staci D. Bilbo

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  1. Staci D. Bilbo
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Correspondence to Staci D. Bilbo.

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Bilbo, S.D. The diverse culinary habits of microglia. Nat Neurosci 21, 1023–1025 (2018). https://doi.org/10.1038/s41593-018-0196-z

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